If you have Windows 10, and a Wacom tablet driver installed (even if you are not using the tablet) :
Be sure that your driver software is up to date. Otherwise the driver may cause mysterious system crashes, even without the tablet attached. That’s because the driver may load as an active Windows service.
My Intuos Pen tablet driver was version 6.3.13w3, dating back to Windows 8. It has to be updated to at least 6.3.15.
I found this out when my system started crashing after an hour or two. Error logs showed that the Wacom driver (service) crashed first, even though I hadn’t attached the tablet for months. Then I looked up the error on the Internet. It was the driver version.