Originally Posted by tiago.dagostini
The amount of content is nearly irrelevant.. how they relate and guide the flow of the viewers eye is all that matters.
I second this and will add that is largely a matter of ordering your values and colors. Simplify them into larger groups or areas. Add a clear hierarchy in your contrasts (in value, color, detail, etc.): highest contrasts in your focal area, lowest contrasts in the peripheral areas.